IRAP therapy, or Interleukin-1 Receptor Antagonist Protein, is a novel approach in treating osteoarthritis (OA) in horses. It's especially helpful in reducing joint inflammation and preventing continued degeneration and progression of osteoarthritis. The procedure begins with drawing blood from the horse that will be treated with IRAP. The blood-filled syringe is specially prepared with glass beads that stimulate production of the antagonist protein and an anticoagulant. The blood is harvested, incubated and centrifuged to separate the serum (abundant with IRAP) from the blood. Typically, IRAP treatments are performed once a week for three weeks, and usually after that time, the horse can return to normal work.